The disinfection and epidemic prevention robot is abbreviated as the disinfection robot. The robot is the carrier, the disinfection system inside the robot generates Atomization spray+UVC+Plasma. The Atomization spray+UVC+Plasma are used to increase the coverage and uniformity of disinfection. It can effectively kill pathogenic microorganisms in the air without dead ends. The set route automatically, efficiently, and accurately disinfects the room and prevents epidemics.